The Functions of Auxilin and Rab11 in Drosophila Suggest That the Fundamental Role of Ligand Endocytosis in Notch Signaling Cells Is Not Recycling

@inproceedings{Banks2011TheFO,
  title={The Functions of Auxilin and Rab11 in Drosophila Suggest That the Fundamental Role of Ligand Endocytosis in Notch Signaling Cells Is Not Recycling},
  author={Susan M. L. Banks and Bomsoo Cho and Suk Ho Eun and Ji-Hoon Lee and Sarah L. Windler and Xuanhua Xie and David Bilder and Janice A. Fischer},
  booktitle={PloS one},
  year={2011}
}
Notch signaling requires ligand internalization by the signal sending cells. Two endocytic proteins, epsin and auxilin, are essential for ligand internalization and signaling. Epsin promotes clathrin-coated vesicle formation, and auxilin uncoats clathrin from newly internalized vesicles. Two hypotheses have been advanced to explain the requirement for ligand endocytosis. One idea is that after ligand/receptor binding, ligand endocytosis leads to receptor activation by pulling on the receptor… CONTINUE READING

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