The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids

@article{Oster2017TheFA,
  title={The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids},
  author={H. Oster and E. Challet and V. Ott and E. Arvat and E. D. de Kloet and D. Dijk and S. Lightman and A. Vgontzas and E. van Cauter},
  journal={Endocrine Reviews},
  year={2017},
  volume={38},
  pages={3 - 45}
}
ESSENTIAL POINTS The daily rhythmicity of plasma glucocorticoid (GC) levels is a strong modulator of many physiological and psychological processes, although its functional significance is poorly understood. The suprachiasmic nuclei of the hypothalamus have been shown to harbor a molecular clock mechanism generating circadian rhythmicity in mammals, but the same mechanism is present in many peripheral tissues and elsewhere in the brain. Mineralocorticoid receptors and glucocorticoid receptors… Expand
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