The Function of V-ATPases in Cancer.

  title={The Function of V-ATPases in Cancer.},
  author={Laura A Stransky and Kristina Cotter and Michael Forgac},
  journal={Physiological reviews},
  volume={96 3},
The vacuolar ATPases (V-ATPases) are a family of proton pumps that couple ATP hydrolysis to proton transport into intracellular compartments and across the plasma membrane. They function in a wide array of normal cellular processes, including membrane traffic, protein processing and degradation, and the coupled transport of small molecules, as well as such physiological processes as urinary acidification and bone resorption. The V-ATPases have also been implicated in a number of disease… CONTINUE READING