The Frank-Starling mechanism is not mediated by changes in rate of cross-bridge detachment.

@article{Wannenburg1997TheFM,
  title={The Frank-Starling mechanism is not mediated by changes in rate of cross-bridge detachment.},
  author={Thomas Wannenburg and Paul M. L. Janssen and Dongsheng Fan and Pieter P de Tombe},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={1997},
  volume={273 5},
  pages={H2428-H2435}
}
We tested the hypothesis that the Frank-Starling relationship is mediated by changes in the rate of cross-bridge detachment in cardiac muscle. We simultaneously measured isometric force development and the rate of ATP consumption at various levels of Ca2+ activation in skinned rat cardiac trabecular muscles at three sarcomere lengths (2.0, 2.1, and 2.2 μm). The maximum rate of ATP consumption was 1.5 nmol ⋅ s-1 ⋅ μl fiber vol-1, which represents an estimated adenosinetriphosphatase (ATPase… Expand
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  • American journal of physiology. Heart and circulatory physiology
  • 2010
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