The Frank--Starling curve.

@article{Noble1978TheFC,
  title={The Frank--Starling curve.},
  author={Mark I M Noble},
  journal={Clinical science and molecular medicine},
  year={1978},
  volume={54 1},
  pages={
          1-7
        }
}
  • M. Noble
  • Published 1978
  • Biology
  • Clinical science and molecular medicine
A basic property of the normal heart is that if its volume is increased, there is an increase in the strength of the contraction. The phenomenon is known as Starling's Law, and as the FrankStarling mechanism. This phenomenon is of great importance. If the heart were unable to increase its output when distended, the distension would become progressively severe. The underlying important relation in the ventri: cular muscle is that between systolic contractile force and muscle (or sarcomere… 

Figures from this paper

The Pressure—Volume Relationship of the Intact Heart

The uniqueness of the pressure-volume diagram as a unique descriptor of left ventricular mechanical function would be invalidated if the slow response of force to length change proved to be present in the intact heart; present data on that point is contradictory between different laboratories.

The cellular basis of the length-tension relation in cardiac muscle.

Frank-Starling Curve

The Frank-Starling mechanism describes a relationship where increasing ventricular filling increases cardiac output. Increased preload increases sarcomere stretch inside cardiac myocytes which

Frank-Starling mechanism, fluid responsiveness, and length-dependent activation: Unravelling the multiscale behaviors with an in silico analysis

A multiscale model of the cardiovascular system is used to untangle the three concepts (length-dependent activation, Frank-Starling, and vascular filling) and reveals a dynamical length dependent activation-driven response to changes in preload, which involves interactions between the cellular, ventricular and cardiovascular levels and thus highlights fundamentally multiscales behaviors.

Systolic elastance and oxygen consumption based on the Alternative Starling Curve

  • P. Kerkhof
  • Biology
    1992 14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • 1992
This work modelled the behavior of the left ventricle on the basis of the experimentally constructed Alternative Starling curve and indicated that oxygen consumption can be realistically predicted under a variety of loading and inotropic conditions of the heart.

Evaluation of Ventricular Function

The heart and peripheral vasculature are seen as a closely integrated system in which the heart acts as a pump, supplying the energy, with small contributions from peripheral and respiratory musculature, for the circulation of blood.

Measurement and Control of Cardiac Output

Although cardiac output can increase only fivefold on severe exercise, the oxygen consumption of the body can increase ten-fold (Table 1.2), which is sufficient to provide the body tissues with oxygen and substrate and to remove the products of metabolism.

Left Ventricular Pressure–Volume and Frank‐Starling Relations in Endurance Athletes: Implications for Orthostatic Tolerance and Exercise Performance

Endurance athletes have greater ventricular diastolic chamber compliance and distensibility than nonathletes and thus operate on the steep portion of their Starling curve, which may be a mechanical, nonautonomic cause of orthostatic intolerance.

Postextrasystolic Potentiation and Its Contribution to the Beat‐to‐Beat Variation of the Pulse During Atrial Fibrillation

This study demonstrates that postextrasystolic potentiation contributes to the characteristic beat-to-beat variation of the pulse in AF.

The effects of isoprenaline, atropine and dobutamine on ventricular volume curves obtained by radionuclide ventriculography.

An index, the mean ejection time, is derived, which is influenced by changes in the shape of the systolic portion of the volume curve but is unchanged when measured from curves treated by different filter bandwidths.

References

SHOWING 1-10 OF 29 REFERENCES

Absence of a plateau in length–tension relationship of rabbit papillary muscle when internal shortening is prevented

A photoelectronic servo apparatus similar to that developed by Gordon et al. is developed for use with papillary muscles to hold constant the length of a segment of preparation during contraction to help determine the physiological basis for this relationship.

Sarcomere dynamics in intact cardiac muscle.

Elastic properties, length-tension relations, and some characteristics of unloaded shortening were measured at the sarcomere level in rat papillary muscles as well as isometric tension and velocity in an unloaded contraction.

A reexamination of the influence of muscle length on myocardial performance.

The conclusion reached in this article is that (in the isolated papillary muscle at least) there can be no perfect index of contractility because the inotropic state of the muscle is strongly influenced by its length.

Sarcomere dynamics in intact cardiac muscle.

Both isometric tension and velocity of unloaded shortening reached their peak values relatively early in the contractile cycle.

Left ventricular force-length relations of isovolumic and ejecting contractions.

Regardless of loading, delta L occurs within the confines of the contractile state-dependent isovolumic force-L relation and where the latter is equivalent to the end-systolic force-length relation.

Dependence of the contractile activation of skinned cardiac cells on the sarcomere length

It is demonstrated that the systolic pressure developed by the heart decreased as its diastolic volume was altered in either direction from an optimum value.

Problems Concerning the Application of Concepts of Muscle Mechanics to the Determination of the Contractile State of the Heart

  • M. Noble
  • Medicine, Biology
    Circulation
  • 1972
The quest for a measure of "contractility" or "contractile state" becomes the quest for an early indication of myocardial disease that may be of prognostic value and open up the possibility of preventive measures to forestall serious myocardials disease and failure.

The Physiological Basis of Starling's Law of the Heart

The work presented is up-to-date and, taken as a whole, provides an excellent synopsis of the state of the art concerning cardiac physiology.

Relation Between Mural Force and Pressure in the Left Ventricle of the Dog

A method for recording the force needed to keep together the two edges of a slit in the ventricle is described, and samples of the force curves are shown, the general features of which are consistent with predictions from the physiology of muscle strips.

The regulation of the heart beat

In the experiments here described, scientists have endeavoured to determine some underlying principle on which the heart's power of selfregulation may depend, or some elementary property of the tissues making up the heart from which the varied behaviouir of the heart under different circumstances can be directly deduced.