The Francisella pathogenicity island.

@article{Nano2007TheFP,
  title={The Francisella pathogenicity island.},
  author={Francis E Nano and Crystal L. Schmerk},
  journal={Annals of the New York Academy of Sciences},
  year={2007},
  volume={1105},
  pages={
          122-37
        }
}
The Francisella pathogenicity island (FPI) is a cluster of 16-19 genes, which is found duplicated in most of the Francisella genomes that have been sequenced. Although 16 FPI genes are highly conserved there are 2-3 putative genes that are absent or interrupted by stop codons in some strains. Francisella strains with experimentally induced mutations in FPI genes are highly attenuated in virulence and show defects in intramacrophage growth. There is experimental evidence indicating that the… CONTINUE READING
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