The Focal Adhesion-Localized CdGAP Regulates Matrix Rigidity Sensing and Durotaxis

@inproceedings{Wormer2014TheFA,
  title={The Focal Adhesion-Localized CdGAP Regulates Matrix Rigidity Sensing and Durotaxis},
  author={Duncan B. Wormer and Kevin A. Davis and James H Henderson and C. Heath Turner},
  booktitle={PloS one},
  year={2014}
}
Motile cells are capable of sensing the stiffness of the surrounding extracellular matrix through integrin-mediated focal adhesions and migrate towards regions of higher rigidity in a process known as durotaxis. Durotaxis plays an important role in normal development and disease progression, including tumor invasion and metastasis. However, the signaling mechanisms underlying focal adhesion-mediated rigidity sensing and durotaxis are poorly understood. Utilizing matrix-coated… CONTINUE READING