The Florey Lecture, 1990. How is the cell division cycle regulated?

@article{Nurse1991TheFL,
  title={The Florey Lecture, 1990. How is the cell division cycle regulated?},
  author={P. Nurse},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={1991},
  volume={332 1264},
  pages={271-6}
}
  • P. Nurse
  • Published 1991 in
    Philosophical transactions of the Royal Society…
It is argued in this lecture that in most eukaryotic cells onset of mitosis is coupled to attainment of a critical cell mass and to completion of the previous S-phase. In fission yeast these controls operate through a regulatory gene network that activates the p34cdc2 protein kinase at mitosis. This is brought about by dephosphorylation of a tyrosine… CONTINUE READING