The Flavonoid Luteolin Worsens Chemical-Induced Colitis in NF-κBEGFP Transgenic Mice through Blockade of NF-κB-Dependent Protective Molecules

@article{Karrasch2007TheFL,
  title={The Flavonoid Luteolin Worsens Chemical-Induced Colitis in NF-κBEGFP Transgenic Mice through Blockade of NF-κB-Dependent Protective Molecules},
  author={Thomas Karrasch and Joo-Sung Kim and Byung Ik Jang and Christian Jobin},
  journal={PLoS ONE},
  year={2007},
  volume={2},
  pages={837 - 848}
}
BACKGROUND The flavonoid luteolin has anti-inflammatory properties both in vivo and in vitro. However, the impact of luteolin on experimental models of colitis is unknown. METHODOLOGY/PRINCIPAL FINDINGS To address the therapeutic impact of luteolin, NF-kappaB(EGFP) transgenic mice were fed a chow diet containing 2% luteolin- or isoflavone-free control… CONTINUE READING