The First Pharmacoepidemiologic Investigations: national drug safety policy in the United States, 1901-1902

@article{Lilienfeld2008TheFP,
  title={The First Pharmacoepidemiologic Investigations: national drug safety policy in the United States, 1901-1902},
  author={David Eugene Lilienfeld},
  journal={Perspectives in Biology and Medicine},
  year={2008},
  volume={51},
  pages={188 - 198}
}
  • D. Lilienfeld
  • Published 4 May 2008
  • Medicine
  • Perspectives in Biology and Medicine
The pharmaceutical industry developed in the late 19th century as a consequence of both scientific and commercial innovations, such as the development of diphtheria antitoxin and the commercialization of smallpox vaccine. Two tetanus outbreaks in 1901-from contaminated diphtheria antitoxin in St. Louis, Missouri, and contaminated smallpox vaccine in Camden, New Jersey-raised public concern about pharmaceutical safety. In St. Louis, errant manufacturing processes were found to be the source of… 
dventitious agents and live viral vectored vaccines : Considerations or archiving samples of biological materials for retrospective nalysis
TLDR
Several prior major cases of vaccine contamination with adventitious agents are summarized and points for consideration on sample archiving are provided.
Restricting the Sale of “Deadly Poisons”: Pharmacists, Drug Regulation, and Narratives of Suffering in the Gilded Age1
TLDR
The origins of state-level regulations controlling the practice of pharmacy and the manufacture and consumption of dangerous drugs in the Gilded Age are examined.
Bridging the Gap Between Validation and Implementation of Non-Animal Veterinary Vaccine Potency Testing Methods
TLDR
A paradigmatic process is presented here, by which interested parties can assess the local regulatory acceptance of methods that reduce animal use and integrate them into quality control testing protocols, or ensure the elimination of peripheral barriers to their use.
General Clinical Trials
TLDR
Observational studies offer helpful information regarding associations that may exist between certain exposures and outcomes and are often considered the “gold standard” of clinical trials.
...
...

References

SHOWING 1-10 OF 26 REFERENCES
PATHOLOGIC EFFECTS OF ELIXIR OF SULFANILAMIDE (DIETHYLENE GLYCOL) POISONING: A CLINICAL AND EXPERIMENTAL CORRELATION: FINAL REPORT
TLDR
According to reports, at least seventy-six human beings in various localities died as a result of poisoning by Elixir of Sulfanilamide-Massengill during the months of September and October 1937.
AN ANALYSIS OF FIFTY-TWO CASES OF TETANUS FOLLOWING VACCINIA.: WITH REFERENCE TO THE SOURCE OF INFECTION. 1839-1902.
TLDR
During the five months that have succeeded the report of this case before the Philadelphia County Medical Society an attempt has been made to ascertain the details of such a number of similar cases, both in recent and past years, as would warrant a conclusion as to the source of the tetanus infection.
Methods of outbreak investigation in the “Era of Bacteriology” 1880–1920
  • A. Hardy
  • History, Medicine
    Sozial- und Präventivmedizin
  • 2005
SummaryThe advent of bacteriological methods in the later 19th century has been seen, on the examples of America and Germany, to have been followed by a new laboratory-based, contact-tracing method
Networks of Innovation
Networks of Innovation offers an historical perspective on the manner in which private-sector organizations have acquired, sustained, and periodically lost the ability to develop, manufacture, and
Adverse Reactions
A Theory of Psychological ReactanceBy Jack W. Brehm. (Social Psychology: a Series of Monographs, Treatises, and Texts.) Pp. x + 135. (New York: Academic Press, Inc.; London: Academic Press, Inc.
Biologics Control Act of 1902
  • The early years of federal food and drug control
  • 1982
Medical Science and Medical Industry
Letter to Dr
  • Joseph McFarland, Jan. 20. In the McFarland Paper
  • 1902
Tetanus and Vaccination - an analytical study of ninety-five Cases of this rare Complication.
TETANUS AND VACCINATION.
...
...