The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. II. An autosomal genome scan for diabetes-related quantitative-trait loci.

@article{Watanabe2000TheFS,
  title={The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. II. An autosomal genome scan for diabetes-related quantitative-trait loci.},
  author={Richard M. Watanabe and Sajalendu Ghosh and Carl D. Langefeld and Timo T. Valle and Elizabeth R. Hauser and Victoria L. Magnuson and Karen L. Mohlke and Kaisa Silander and Delphine S. Ally and Peter S. Chines and J Blaschak-Harvan and Julie A. Douglas and William Duren and Michael P Epstein and Tasha E Fingerlin and Hong Kaleta and Ethan M. Lange and Chun Li and Richard C. McEachin and Heather M Stringham and E Trager and Peggy P White and James E. Balow and Gunther Birznieks and J Chang and W Eldridge},
  journal={American journal of human genetics},
  year={2000},
  volume={67 5},
  pages={1186-200}
}
Type 2 diabetes mellitus is a complex disorder encompassing multiple metabolic defects. We report results from an autosomal genome scan for type 2 diabetes-related quantitative traits in 580 Finnish families ascertained for an affected sibling pair and analyzed by the variance components-based quantitative-trait locus (QTL) linkage approach. We analyzed diabetic and nondiabetic subjects separately, because of the possible impact of disease on the traits of interest. In diabetic individuals, our… CONTINUE READING
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