The Fenfluramine Metabolite (+)-Norfenfluramine Is Vasoactive

  title={The Fenfluramine Metabolite (+)-Norfenfluramine Is Vasoactive},
  author={W. Ni and M. Li and K. Thakali and G. Fink and S. Watts},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={845 - 852}
  • W. Ni, M. Li, +2 authors S. Watts
  • Published 2004
  • Chemistry, Medicine
  • Journal of Pharmacology and Experimental Therapeutics
  • The anorexigen (+)-fenfluramine was used for treatment of obesity until the association of use with valvular heart disease and primary pulmonary hypertension. (+)-Fenfluramine has been found in Chinese and Korean slimming pills. The hepatic metabolite of (+)-fenfluramine, (+)-norfenfluramine, has affinity for 5-hydroxytryptamine (5-HT)2A and 5-HT2B receptors. We tested the hypothesis that (+)-norfenfluramine contracts arterial smooth muscle in a 5-HT receptor-dependent manner and acts as a… CONTINUE READING
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