The Feline Thyroid Gland: A Model for Endocrine Disruption by Polybrominated Diphenyl Ethers (PBDEs)?

@article{Mensching2012TheFT,
  title={The Feline Thyroid Gland: A Model for Endocrine Disruption by Polybrominated Diphenyl Ethers (PBDEs)?},
  author={Donna Mensching and Margaret Slater and John W. Scott and Duncan C. Ferguson and Val Richard Beasley},
  journal={Journal of Toxicology and Environmental Health, Part A},
  year={2012},
  volume={75},
  pages={201 - 212}
}
The role of polybrominated diphenyl ethers (PBDE) was investigated in the occurrence of feline hyperthyroidism (FH) by evaluating 15 PBDE congeners in serum from 62 client-owned (21 euthyroid, 41 hyperthyroid) and 10 feral cats. Total serum PBDE concentrations in euthyroid cats were not significantly different from those of hyperthyroid cats. Total serum PBDE in feral cats were significantly lower than in either of the groups of client-owned cats. Total serum PBDE did not correlate with serum… 
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Higher PBDE serum concentrations may be associated with feline hyperthyroidism in Swedish cats.
TLDR
The statistics indicate an association between elevated PBDE concentrations in the cats and FH, and it is intriguing, and beyond explanation, why the flame retardant BB-209 (discontinued in 2000) is present in all of the cat serum samples in concentrations similar to BDE-209.
Evaluation of polybrominated diphenyl ethers (PBDEs) in matched cat sera and house dust samples: investigation of a potential link between PBDEs and spontaneous feline hyperthyroidism.
Association of Polybrominated Diphenyl Ethers (PBDEs) and Polychlorinated Biphenyls (PCBs) with Hyperthyroidism in Domestic Felines, Sentinels for Thyroid Hormone Disruption
TLDR
Observational findings support the hypothesis that PBDEs and PCBs may contribute to the etiopathogenesis of hyperthyroidism in felines.
Organohalogenated contaminants in domestic cats' plasma in relation to spontaneous acromegaly and type 2 diabetes mellitus: a clue for endocrine disruption in humans?
Organohalogen Compounds in Pet Dog and Cat: Do Pets Biotransform Natural Brominated Products in Food to Harmful Hydroxlated Substances?
TLDR
The present study suggests that pet cats are exposed to MeO-PBDEs through cat food products containing fish flavors and that the OH- PBDEs in cat blood are derived from the CYP-dependent demethylation of naturally occurring MeO -PBDE congeners, not from the hydroxylation of PBDES.
Serum concentration of bisphenol A in elderly cats and its association with clinicopathological findings
TLDR
The age of the cats was revealed as a significant factor affecting BPA concentration and mature cats had the highest levels and a significantly higher concentration of BPA was found in cats living strictly indoors and in cats fed canned food.
Biotransformation of Brominated Compounds by Pet Dogs and Cats
TLDR
The profiles and tissue distribution of PBDEs and metabolites are described for both species, and possible explanations for the differences observed between these pets are put forward.
Polybrominated Diphenyl Ether (PBDE)-Induced Suppression of Phosphoenolpyruvate Carboxykinase (PEPCK) Decreases Hepatic Glyceroneogenesis and Disrupts Hepatic Lipid Homeostasis
TLDR
It is suggested that DE-71-induced inhibition of hepatic PEPCK activity alters lipid metabolism by redirecting fatty acids away from esterification and storage toward ketone synthesis.
Temporal Changes of PBDE Levels in California House Cats and a Link to Cat Hyperthyroidism.
TLDR
The findings indicate that the current levels of PBDEs, as well as PCBs and OCPs, may still pose health effects for house cats and, possibly, humans.
Cats' Internal Exposure to Selected Brominated Flame Retardants and Organochlorines Correlated to House Dust and Cat Food.
TLDR
This is the first time a correlation between cat serum levels and household dust has been established, a finding that supports the hypothesis that dust is a significant exposure route for cats.
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