The Fasting Hyperglycaemia Study: III. Randomized controlled trial of sulfonylurea therapy in subjects with increased but not diabetic fasting plasma glucose.

@article{Karunakaran1997TheFH,
  title={The Fasting Hyperglycaemia Study: III. Randomized controlled trial of sulfonylurea therapy in subjects with increased but not diabetic fasting plasma glucose.},
  author={Sunitha Karunakaran and Maggie S Hammersley and Richard J. Morris and Robert C. Turner and Rury R Holman},
  journal={Metabolism: clinical and experimental},
  year={1997},
  volume={46 12 Suppl 1},
  pages={56-60}
}
Self-referred subjects (N = 227) thought to be at increased risk of developing diabetes who had fasting plasma glucose (FPG) values in the range of 5.5 to 7.7 mmol.L-1 on two consecutive occasions 2 weeks apart were randomized to sulfonylurea therapy (gliclazide, < or = 160 mg.d-1) or to a control group allocated either to double-blind placebo or to no tablets. Subjects were randomly allocated also to reinforced or basic healthy-living advice in a factorial design. A total of 201 subjects have… CONTINUE READING

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