The Fast Changing Landscape of Sequencing Technologies and Their Impact on Microbial Genome Assemblies and Annotation

@inproceedings{Mavromatis2012TheFC,
  title={The Fast Changing Landscape of Sequencing Technologies and Their Impact on Microbial Genome Assemblies and Annotation},
  author={Konstantinos Mavromatis and Miriam L. Land and Thomas S. Brettin and Daniel J. Quest and Alex Copeland and Alicia Clum and Lynne Goodwin and Tanja Woyke and Alla Lapidus and Hans Peter Klenk and Robert W. Cottingham and Nikos C Kyrpides},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND The emergence of next generation sequencing (NGS) has provided the means for rapid and high throughput sequencing and data generation at low cost, while concomitantly creating a new set of challenges. The number of available assembled microbial genomes continues to grow rapidly and their quality reflects the quality of the sequencing technology used, but also of the analysis software employed for assembly and annotation. METHODOLOGY/PRINCIPAL FINDINGS In this work, we have explored… CONTINUE READING
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