The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells

Abstract

Fas ligand (FasL) is a type II transmembrane protein belonging to the tumor necrosis factor family. Its binding to the cognate Fas receptor triggers the apoptosis that plays a pivotal role in the maintenance of immune system homeostasis. The cell death-inducing property of FasL has been associated with its extracellular domain, which can be cleaved off by… (More)
DOI: 10.1038/sj.cdd.4402175

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