The Fanconi anemia polypeptide, FAC, binds to the cyclin-dependent kinase, cdc2.

@article{Kupfer1997TheFA,
  title={The Fanconi anemia polypeptide, FAC, binds to the cyclin-dependent kinase, cdc2.},
  author={Gary M. Kupfer and Tadashi Yamashita and Dieter Naf and Ahmed Talal Suliman and Shigetaka Asano and Alan D D'Andrea},
  journal={Blood},
  year={1997},
  volume={90 3},
  pages={1047-54}
}
Fanconi anemia (FA) is an autosomal recessive disorder characterized by developmental defects, bone marrow failure, and cancer susceptibility. Cells derived from FA patients are sensitive to crosslinking agents and have a prolonged G2 phase, suggesting a cell cycle abnormality. Although transfection of type-C FA cells with the FAC cDNA corrects these cellular abnormalities, the molecular function of the FAC polypeptide remains unknown. In the current study we show that expression of the FAC… CONTINUE READING
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