The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair.

@article{Knipscheer2009TheFA,
  title={The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair.},
  author={Puck Knipscheer and Markus R{\"a}schle and Agata Smogorzewska and Milica Enoiu and The Vinh Ho and Orlando D Sch{\"a}rer and Stephen J Elledge and Johannes C. Walter},
  journal={Science},
  year={2009},
  volume={326 5960},
  pages={1698-701}
}
Fanconi anemia is a human cancer predisposition syndrome caused by mutations in 13 Fanc genes. The disorder is characterized by genomic instability and cellular hypersensitivity to chemicals that generate DNA interstrand cross-links (ICLs). A central event in the activation of the Fanconi anemia pathway is the mono-ubiquitylation of the FANCI-FANCD2 complex, but how this complex confers ICL resistance remains enigmatic. Using a cell-free system, we showed that FANCI-FANCD2 is required for… CONTINUE READING
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