The Fanconi anemia group A protein modulates homologous repair of DNA double-strand breaks in mammalian cells.

@article{Yang2005TheFA,
  title={The Fanconi anemia group A protein modulates homologous repair of DNA double-strand breaks in mammalian cells.},
  author={Yun-Gui Yang and Zdenko Herceg and Koji Nakanishi and Ilja Demuth and Colette Piccoli and Jocelyne Michelon and Gabriele Hildebrand and Maria Jasin and M. Digweed and Zhao-Qi Wang},
  journal={Carcinogenesis},
  year={2005},
  volume={26 10},
  pages={1731-40}
}
Fanconi anemia (FA) cells exhibit hypersensitivity to DNA interstrand cross-links (ICLs) and high levels of chromosome instability. FA gene products have been shown to functionally or physically interact with BRCA1, RAD51 and the MRE11/RAD50/NBS1 complex, suggesting that the FA complex may be involved in the repair of DNA double-strand breaks (DSBs). Here, we have investigated specifically the function of the FA group A protein (FANCA) in the repair of DSBs in mammalian cells. We show that the… CONTINUE READING

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