The Fanconi anemia core complex forms four complexes of different sizes in different subcellular compartments.

@article{Thomashevski2004TheFA,
  title={The Fanconi anemia core complex forms four complexes of different sizes in different subcellular compartments.},
  author={Andrei Thomashevski and Anthony A. High and Mary T. Drozd and Jeffrey Shabanowitz and Donald F. Hunt and Patrick A. Grant and Gary M. Kupfer},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 25},
  pages={26201-9}
}
Fanconi anemia (FA) is an autosomal recessive disease marked by congenital defects, bone marrow failure, and cancer susceptibility. FA cells exhibit a characteristic hypersensitivity to DNA crosslinking agents such as mitomycin C. The molecular mechanism for the disease remains elusive, but at least 6 FA proteins are known to be part of what is termed the FA core complex. We used affinity pulldown of FLAG-FANCA to pull down the FA complex from whole-cell extracts. Mass spectroscopy detected… CONTINUE READING

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