The Fanconi anemia/BRCA pathway: a coordinator of cross-link repair.

  title={The Fanconi anemia/BRCA pathway: a coordinator of cross-link repair.},
  author={Kanchan D. Mirchandani and Alan D' Andrea},
  journal={Experimental cell research},
  volume={312 14},
Fanconi anemia (FA) is a rare inherited disease characterized by genomic instability and markedly increased cancer risk. Efforts to elucidate the molecular basis of FA have unearthed a novel DNA damage response pathway, the integrity of which is critical for cellular resistance to DNA cross-linking agents. Despite significant progress in uncovering the molecular events underlying FA, the precise function of this pathway in DNA repair is unknown. This article will review evidence implicating FA… CONTINUE READING

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