The Fanconi anaemia/BRCA pathway

  title={The Fanconi anaemia/BRCA pathway},
  author={Alan D D'Andrea and Markus Grompe},
  journal={Nature Reviews Cancer},
Fanconi anaemia (FA) is a rare genetic cancer-susceptibility syndrome that is characterized by congenital abnormalities, bone-marrow failure and cellular sensitivity to DNA crosslinking agents. Seven FA-associated genes have recently been cloned, and their products were found to interact with well-known DNA-damage-response proteins, including BRCA1, ATM and NBS1. The FA proteins could therefore be involved in the cell-cycle checkpoint and DNA-repair pathways. Recent studies implicate the FA… CONTINUE READING
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