The Family of IL-10-secreting CD4+ T cells.

@article{Fujio2010TheFO,
  title={The Family of IL-10-secreting CD4+ T cells.},
  author={Keishi Fujio and Tomohisa Okamura and Kazuhiko Yamamoto},
  journal={Advances in immunology},
  year={2010},
  volume={105},
  pages={99-130}
}
Regulatory T cells (Treg cells) play critical roles in the induction of peripheral tolerance to self- and foreign antigens. Naturally occurring CD4(+)CD25(+) Treg cells, which characteristically express the transcription factor forkhead box protein P3 (Foxp3), have been studied intensively because their deficiency abrogates self-tolerance and causes autoimmune disease. However, several lines of evidence suggest that additional important mechanisms other than the Foxp3 system are required to… CONTINUE READING

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