The Family of IL-10-secreting CD4+ T cells.

  title={The Family of IL-10-secreting CD4+ T cells.},
  author={Keishi Fujio and Tomohisa Okamura and Kazuhiko Yamamoto},
  journal={Advances in immunology},
Regulatory T cells (Treg cells) play critical roles in the induction of peripheral tolerance to self- and foreign antigens. Naturally occurring CD4(+)CD25(+) Treg cells, which characteristically express the transcription factor forkhead box protein P3 (Foxp3), have been studied intensively because their deficiency abrogates self-tolerance and causes autoimmune disease. However, several lines of evidence suggest that additional important mechanisms other than the Foxp3 system are required to… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 73 extracted citations

Similar Papers

Loading similar papers…