The Factor VIII acute phase response requires the participation of NFkappaB and C/EBP.

@article{Begbie2000TheFV,
  title={The Factor VIII acute phase response requires the participation of NFkappaB and C/EBP.},
  author={M. Begbie and C. Notley and S. Tinlin and L. Sawyer and D. Lillicrap},
  journal={Thrombosis and haemostasis},
  year={2000},
  volume={84 2},
  pages={
          216-22
        }
}
Coagulation Factor VIII is an acute phase protein in humans that has recently been shown to be transcriptionally responsive to interleukin-6. In this study, we have demonstrated that the human Factor VIII promoter is activated in cultured hepatocytes exposed to bacterial lipopolysaccharide (LPS). Deletion analysis has narrowed the LPS-responsive element of the Factor VIII promoter to a small region which contains two C/EBP binding sites and an adjacent NFkappaB binding site. Mutation of the… Expand

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