The FRA2C common fragile site maps to the borders of MYCN amplicons in neuroblastoma and is associated with gross chromosomal rearrangements in different cancers.

@article{Blumrich2011TheFC,
  title={The FRA2C common fragile site maps to the borders of MYCN amplicons in neuroblastoma and is associated with gross chromosomal rearrangements in different cancers.},
  author={Anne Blumrich and Marc Zapatka and Lena M Brueckner and Diana Zheglo and Manfred Dipl Phys Schwab and Larissa Savelyeva},
  journal={Human molecular genetics},
  year={2011},
  volume={20 8},
  pages={
          1488-501
        }
}
Common fragile sites (cFS) represent chromosomal regions that are prone to breakage after partial inhibition of DNA synthesis. Activation of cFS is associated with various forms of DNA instability in cancer cells, and is thought to be an initiating event in the generation of DNA damage in early-stage tumorigenesis. Only a few cFS have been fully characterized despite the growing interest in cFS instability in cancer genomes. In this study, six-color fluorescence in situ hybridization revealed… CONTINUE READING

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