The FPR2-specific ligand MMK-1 activates the neutrophil NADPH-oxidase, but triggers no unique pathway for opening of plasma membrane calcium channels.

@article{Karlsson2009TheFL,
  title={The FPR2-specific ligand MMK-1 activates the neutrophil NADPH-oxidase, but triggers no unique pathway for opening of plasma membrane calcium channels.},
  author={Jennie Karlsson and Anna-Lena Stenfeldt and M J Rabiet and Johan Bylund and Huamei Forsman and Claes Dahlgren},
  journal={Cell calcium},
  year={2009},
  volume={45 5},
  pages={431-8}
}
Human neutrophils express formyl peptide receptor 1 and 2 (FPR1 and FPR2), two highly homologous G-protein-coupled cell surface receptors important for the cellular recognition of chemotactic peptides. They share many functional as well as signal transduction features, but some fundamental differences have been described. One such difference was recently presented when the FPR2-specific ligand MMK-1 was shown to trigger a unique signal in neutrophils [S. Partida-Sanchez, P. Iribarren, M.E… CONTINUE READING
Highly Cited
This paper has 152 citations. REVIEW CITATIONS

7 Figures & Tables

Connections & Topics

Mentioned Connections BETA
Plasma membraneIs associated anatomy of gene productErbB Receptors
In contrast to earlier findings we show that the transient rise in intracellular free calcium induced by MMK-1 involves both a release of calcium from intracellular stores and an opening of channels in the plasma membrane . The same pattern was obtained with another characterized FPR2 ligand , WKYMVM , and it is also obvious that the two formyl peptide receptor family members trigger the same type of calcium response in human neutrophils .
Human neutrophils express formyl peptide receptor 1 and 2 ( FPR1 and FPR2 ) , two highly homologous G - protein - coupled cell surface receptors important for the cellular recognition of chemotactic peptides .
All Topics

Statistics

050100201020112012201320142015201620172018
Citations per Year

153 Citations

Semantic Scholar estimates that this publication has 153 citations based on the available data.

See our FAQ for additional information.