The FNR modules contribute to control nitric oxide synthase catalysis revealed by chimera enzymes.

Abstract

The reductase domains of neuronal NOS, endothelial NOS and two constitutive nitric oxide synthase (cNOS) share higher sequence similarity (>60%). In order to evaluate the role of ferredoxin‑NADP+ reductase (FNR) module in adjusting NOS catalytic activities, chimeras were by interchanging the FNR‑like module between endothelial NOS and neuronal NOS in the… (More)
DOI: 10.3892/mmr.2017.7745

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