The FMR2 gene, FRAXE and non-specific X-linked mental retardation: clinical and molecular aspects.

@article{Gcz2000TheFG,
  title={The FMR2 gene, FRAXE and non-specific X-linked mental retardation: clinical and molecular aspects.},
  author={Jozef G{\'e}cz},
  journal={Annals of human genetics},
  year={2000},
  volume={64 Pt 2},
  pages={95-106}
}
FRAXE fragile site associated mental retardation remains unique among X-linked mental retardation phenotypes due to its very mild to borderline nature (50< IQ< 85). It is the most prevalent form of non-specific X-linked mental retardation so far delineated, with an estimated incidence of at least 1/50-100,000 males, and with more than 50 families known worldwide. The FRAXE site is within, or immediately adjacent to, the 5' untranslated region of the FMR2 gene. Hyperexpansion of the FRAXE CCG… CONTINUE READING

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