The FHIT Gene, Spanning the Chromosome 3p14.2 Fragile Site and Renal Carcinoma–Associated t(3;8) Breakpoint, Is Abnormal in Digestive Tract Cancers

@article{Ohta1996TheFG,
  title={The FHIT Gene, Spanning the Chromosome 3p14.2 Fragile Site and Renal Carcinoma–Associated t(3;8) Breakpoint, Is Abnormal in Digestive Tract Cancers},
  author={M. Ohta and H. Inoue and M. Cotticelli and K. Kastury and R. Baffa and J. Palazzo and Z. Siprashvili and M. Mori and P. McCue and T. Druck and C. Croce and K. Huebner},
  journal={Cell},
  year={1996},
  volume={84},
  pages={587-597}
}
A 200-300 kb region of chromosome 3p14.2, including the fragile site locus FRA3B, is homozygously deleted in multiple tumor-derived cell lines. Exon amplification from cosmids covering this deleted region allowed identification of the human FHIT gene, a member of ther histidine triad gene family, which encodes a protein with 69% similarity to an S. pombe enzyme, diadenosine 5', 5''' P1, P4-tetraphosphate asymmetrical hydrolase. The FHIT locus is composed of ten exons distributed over at least… Expand
Precise localization of the FHIT gene to the common fragile site at 3p14.2 (FRA3B) and characterization of homozygous deletions within FRA3B that affect FHIT transcription in tumor cell lines
TLDR
Evidence is provided that breakage and rearrangement within the FRA3B fragile site sequences result in alterations of FHIT and are likely to be involved in carcinogenesis. Expand
FHIT gene and the FRA3B region are not involved in the genetics of renal cell carcinomas
TLDR
The FHIT gene locus at 3p14.2 covers about 500 kb, including the fragile site FRA3B and the constitutional t(3;8) breakpoint associated with the development of multiple renal cell carcinomas (RCC); this gene has been suggested to function as a tumor suppressor. Expand
Homozygous deletion but not mutation of exons 5 and 8 of the fragile histidine triad (FHIT) gene is associated with features of differentiated thyroid carcinoma.
TLDR
Exons 5 and 8 of FHIT are key target regions of deletion, homozygous deletions of exon 5 and exon 8 may be good biomarkers for the biological behavior of DTC, and point mutation of these exons may not be involved in the inactivation of the FHit gene in DTC. Expand
Contig array CGH at 3p14.2 points to the FRA3B/FHIT common fragile region as the target gene in diffuse large B-cell lymphoma
TLDR
Findings indicate that loss of genomic material at 3q14.2 is responsible for exon losses of the FHIT gene, and genomic loss of the HIT gene is one of the causes of the generation of aberrant transcripts. Expand
The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8.
  • R. Gemmill, J. West, +5 authors H. Drabkin
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1998
TLDR
It is shown that the 8q24.1 breakpoint region encodes a 664-aa multiple membrane spanning protein, TRC8, with similarity to the hereditary basal cell carcinoma/segment polarity gene, patched, which might function as a signaling receptor and other pathway members, to be defined, are mutation candidates in malignant diseases involving the kidney and thyroid. Expand
Location of candidate tumour suppressor gene loci at chromosomes 3p, 8p and 9p for oral squamous cell carcinomas
TLDR
A more limited analysis of polymorphic sequences at 8p and 9p supports the existence of at least 2 areas that harbour tumour suppressor genes at 7p and evidence that additional targets for deletion reside centromeric and telomeric to the p16 gene at 9p21. Expand
Frequent breakpoints in the 3p14.2 fragile site, FRA3B, in pancreatic tumors.
TLDR
There appears to be a dramatic clustering of chromosomal breakpoints at 3pl4.2 in and immediately distal to FRA3B in pancreatic cancer, and no homozygous deletions were detected in this region. Expand
The DIRC1 gene at chromosome 2q33 spans a familial RCC-associated t(2;3)(q33;q21) chromosome translocation
AbstractA reciprocal, balanced, constitutional chromosome translocation, t(2;3)(q33;q21), which is associated with familial clear cell renal cancer, has been described and the genomic regionsExpand
Frequent Breakpoints in the 3 pl 4 . 2 Fragile Site , FRA 3 B , in Pancreatic Tumors 1
FKA3B, at chromosomal band 3pl4.2, is the most active common fragile site in the human genome. Homozygous deletions in the region of FRA3B have been observed in many types of solid tumors. Recently,Expand
Analysis of the fragile histidine triad gene in primary gastric carcinomas and gastric carcinoma cell lines
TLDR
The results suggest that FHIT gene abnormalities are infrequent in primary gastric carcinomas and that the frequent homozygous deletions seen in cell lines might simply reflect the plasticity of the genome at FRA3B under culture conditions. Expand
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TLDR
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