The FGL2-FcgammaRIIB pathway: a novel mechanism leading to immunosuppression.

  title={The FGL2-FcgammaRIIB pathway: a novel mechanism leading to immunosuppression.},
  author={Hao Liu and Itay Shalev and J. Perez Manuel and Wei He and Elisa Leung and Jennifer A. Crookshank and Ming Feng Liu and Jun Diao and Mark Cattral and David A. Clark and David E. Isenman and Reginald M Gorczynski and David Grant and Li Zhong Zhang and Melville J Phillips and Myron I Cybulsky and Gary A. Levy},
  journal={European journal of immunology},
  volume={38 11},
Fibrinogen-like protein 2 (FGL2) is a multifunctional protein, which has been implicated in the pathogenesis of allograft and xenograft rejection. Previously, FGL2 was shown to inhibit maturation of BM-derived DC and T-cell proliferation. The mechanism of the immunosuppressive activity of FGL2 remains poorly elucidated. Here, we focus on identification of FGL2-specific receptor(s) and their ability to modulate APC activity and allograft survival. Using flow cytometry and surface plasmon… CONTINUE READING

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