The FGF23–Klotho axis: endocrine regulation of phosphate homeostasis


Appropriate levels of phosphate in the body are maintained by the coordinated regulation of the bone-derived growth factor FGF23 and the membrane-bound protein Klotho. The endocrine actions of FGF23, in association with parathyroid hormone and vitamin D, mobilize sodium–phosphate cotransporters that control renal phosphate transport in proximal tubular… (More)
DOI: 10.1038/nrendo.2009.196


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