The FGF-2-triggered protection of cardiac subsarcolemmal mitochondria from calcium overload is mitochondrial connexin 43-dependent.

@article{Srisakuldee2014TheFP,
  title={The FGF-2-triggered protection of cardiac subsarcolemmal mitochondria from calcium overload is mitochondrial connexin 43-dependent.},
  author={Wattamon Srisakuldee and Zhanna Makazan and Barbara E. Nickel and Feixiong Zhang and James A. Thliveris and Kishore B. S. Pasumarthi and Elissavet Kardami},
  journal={Cardiovascular research},
  year={2014},
  volume={103 1},
  pages={72-80}
}
AIMS Fibroblast growth factor 2 (FGF-2) protects the heart from ischaemia- and reperfusion-induced cell death by a mechanism linked to protein kinase C (PKC)ε-mediated connexin 43 (Cx43) phosphorylation. Cx43 localizes predominantly to gap junctions, but has also been detected at subsarcolemmal (SSM), but not interfibrillar (IFM), mitochondria, where it is considered important for cardioprotection. We have now examined the effect of FGF-2 administration to the heart on resistance to calcium… CONTINUE READING