The FE65 proteins and Alzheimer's disease.

  title={The FE65 proteins and Alzheimer's disease.},
  author={Declan M McLoughlin and Christopher J Miller},
  journal={Journal of neuroscience research},
  volume={86 4},
The FE65s (FE65, FE65L1, and FE65L2) are a family of multidomain adaptor proteins that form multiprotein complexes with a range of functions. FE65 is brain-enriched, whereas FE65L1 and FE65L2 are more widely expressed. All three members contain a WW domain and two PTB domains. Through the PTB2 domain, they all interact with the Alzheimer's disease amyloid precursor protein (APP) intracellular domain (AICD) and can alter APP processing. After sequential proteolytic processing of membrane-bound… CONTINUE READING


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