The FATP1–DGAT2 complex facilitates lipid droplet expansion at the ER–lipid droplet interface

@inproceedings{Xu2012TheFC,
  title={The FATP1–DGAT2 complex facilitates lipid droplet expansion at the ER–lipid droplet interface},
  author={Ningyi Xu and Shaobing O. Zhang and Ronald A. Cole and Sean A. McKinney and Fengli Guo and Joel T. Haas and Sudheer Bobba and Robert V Farese and Ho Yi Mak},
  booktitle={The Journal of cell biology},
  year={2012}
}
At the subcellular level, fat storage is confined to the evolutionarily conserved compartments termed lipid droplets (LDs), which are closely associated with the endoplasmic reticulum (ER). However, the molecular mechanisms that enable ER-LD interaction and facilitate neutral lipid loading into LDs are poorly understood. In this paper, we present evidence that FATP1/acyl-CoA synthetase and DGAT2/diacylglycerol acyltransferase are components of a triglyceride synthesis complex that facilitates… CONTINUE READING
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