The F-box protein Slimb controls the levels of clock proteins Period and Timeless

@article{Grima2002TheFP,
  title={The F-box protein Slimb controls the levels of clock proteins Period and Timeless},
  author={B. Grima and A. Lamouroux and E. Ch{\'e}lot and C. Papin and B. Limbourg-Bouchon and F. Rouyer},
  journal={Nature},
  year={2002},
  volume={420},
  pages={178-182}
}
  • B. Grima, A. Lamouroux, +3 authors F. Rouyer
  • Published 2002
  • Medicine, Biology
  • Nature
  • The Drosophila circadian clock is driven by daily fluctuations of the proteins Period and Timeless, which associate in a complex and negatively regulate the transcription of their own genes. Protein phosphorylation has a central role in this feedback loop, by controlling Per stability in both cytoplasmic and nuclear compartments as well as Per/Tim nuclear transfer. However, the pathways regulating degradation of phosphorylated Per and Tim are unknown. Here we show that the product of the slimb… CONTINUE READING

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