The F-box protein Slimb controls the levels of clock proteins Period and Timeless

@article{Grima2002TheFP,
  title={The F-box protein Slimb controls the levels of clock proteins Period and Timeless},
  author={Brigitte Grima and Annie Lamouroux and Elisabeth Chélot and Christian Papin and Bernadette Limbourg-Bouchon and François Rouyer},
  journal={Nature},
  year={2002},
  volume={420},
  pages={178-182}
}
The Drosophila circadian clock is driven by daily fluctuations of the proteins Period and Timeless, which associate in a complex and negatively regulate the transcription of their own genes. Protein phosphorylation has a central role in this feedback loop, by controlling Per stability in both cytoplasmic and nuclear compartments as well as Per/Tim nuclear transfer. However, the pathways regulating degradation of phosphorylated Per and Tim are unknown. Here we show that the product of the slimb… 
Post-Translational Regulation and Nuclear Entry of TIMELESS and PERIOD Are Affected in New timeless Mutant
TLDR
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TLDR
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TLDR
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TLDR
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Ribosomal S6 Kinase Cooperates with Casein Kinase 2 to Modulate the Drosophila Circadian Molecular Oscillator
TLDR
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The Double-Time Protein Kinase Regulates the Subcellular Localization of the Drosophila Clock Protein Period
TLDR
In this study, control of PER subcellular localization in Drosophila clock cells in vivo is examined and it is found that PER can translocate to the nucleus in tim01 null mutants but only if DBT kinase activity is inhibited, and nuclear PER is a potent transcriptional repressor in dbt mutants in vivo without TIM.
Post-translational regulation of the Drosophila circadian clock requires protein phosphatase 1 ( PP 1 )
TLDR
A modified model for post-translational regulation of the Drosophila clock is proposed, in which PP1 is critical for the rhythmic abundance of TIM/PER while PP2A also regulates the nuclear translocation of tim/PER.
Kinetics of Doubletime Kinase-dependent Degradation of the Drosophila Period Protein*
TLDR
The study provides a simple model in which the changes in Drosophila behavioral rhythms can be explained solely by changes in the rate of PER degradation, which resembles that with wild-type DBT.
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