The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription.

@article{Lehr2003TheFP,
  title={The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription.},
  author={Natalie von der Lehr and Sara Johansson and Siqin Wu and Fuad Bahram and Alina Castell and Cihan Cetinkaya and Per Hydbring and Ingrid Weidung and Keiko Nakayama and Keiichi I Nakayama and Ola S{\"o}derberg and Tom Klaus Kerppola and L. Larsson},
  journal={Molecular cell},
  year={2003},
  volume={11 5},
  pages={1189-200}
}
The transcription regulatory oncoprotein c-Myc controls genes involved in cell growth, apoptosis, and oncogenesis. c-Myc is turned over very quickly through the ubiquitin/proteasome pathway. The proteins involved in this process are still unknown. We have found that Skp2 interacts with c-Myc and participates in its ubiquitylation and degradation. The interaction between Skp2 and c-Myc occurs during the G1 to S phase transition of the cell cycle in normal lymphocytes. Surprisingly, Skp2 enhances… CONTINUE READING
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