The F-BAR domains from srGAP1, srGAP2 and srGAP3 regulate membrane deformation differently.

@article{CoutinhoBudd2012TheFD,
  title={The F-BAR domains from srGAP1, srGAP2 and srGAP3 regulate membrane deformation differently.},
  author={Jaeda C Coutinho-Budd and Vladimir Ghukasyan and Mark J. Zylka and Franck Polleux},
  journal={Journal of cell science},
  year={2012},
  volume={125 Pt 14},
  pages={3390-401}
}
Coordination of membrane deformation and cytoskeletal dynamics lies at the heart of many biological processes critical for cell polarity, motility and morphogenesis. We have recently shown that Slit-Robo GTPase-activating protein 2 (srGAP2) regulates neuronal morphogenesis through the ability of its F-BAR domain to regulate membrane deformation and induce filopodia formation. Here, we demonstrate that the F-BAR domains of two closely related family members, srGAP1 and srGAP3 [designated F-BAR(1… CONTINUE READING

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