The Extracellular Domain of Smoothened Regulates Ciliary Localization and Is Required for High-Level Hh Signaling

@article{Aanstad2009TheED,
  title={The Extracellular Domain of Smoothened Regulates Ciliary Localization and Is Required for High-Level Hh Signaling},
  author={Pia Aanstad and Nicole Santos and Kevin C. Corbit and Paul J. Scherz and Le A. Trinh and Willi Salvenmoser and Jan Huisken and Jeremy F Reiter and Didier Y. R. Stainier},
  journal={Current Biology},
  year={2009},
  volume={19},
  pages={1034-1039}
}
Members of the Hedgehog (Hh) family of secreted proteins function as morphogens to pattern developing tissues and control cell proliferation. The seven-transmembrane domain (7TM) protein Smoothened (Smo) is essential for the activation of all levels of Hh signaling. However, the mechanisms by which Smo differentially activates low- or high-level Hh signaling are not known. Here we show that a newly identified mutation in the extracellular domain (ECD) of zebrafish Smo attenuates Smo signaling… CONTINUE READING