The Expression and Clinical Outcome of pCHK2-Thr68 and pCDC25C-Ser216 in Breast Cancer

@inproceedings{Jiang2016TheEA,
  title={The Expression and Clinical Outcome of pCHK2-Thr68 and pCDC25C-Ser216 in Breast Cancer},
  author={Huayong Jiang and Bin Wang and Fuli Zhang and Yuanyu Qian and Chia-Chen Chuang and Mingzhen Ying and Yajie Wang and Li Zuo},
  booktitle={International journal of molecular sciences},
  year={2016}
}
Checkpoint kinase 2 (CHK2) and cell division cycle 25C (CDC25C) are two proteins involved in the DNA damage response pathway, playing essential roles in maintaining genome integrity. As one of the major hallmarks of abnormal cellular division, genomic instability occurs in most cancers. In this study, we identified the functional expression of pCHK2-Thr68 and pCDC25C-Ser216 in breast cancer, as well as its association with breast cancer survival. Tissue microarray analysis using… CONTINUE READING

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