The Expanding World of N-MYC-Driven Tumors.

  title={The Expanding World of N-MYC-Driven Tumors.},
  author={David S. Rickman and Johannes Hubertus Schulte and Martin Eilers},
  journal={Cancer discovery},
  volume={8 2},
Enhanced and deregulated expression of N-MYC, a member of the MYC family of transcription factors, drives the development of multiple tumors, including tumors of the nervous and hematologic systems and neuroendocrine tumors in other organs. This review summarizes the cell-of-origin, biological features, associated signaling pathways, and current treatment strategies for N-MYC-driven tumors. We also highlight biological differences within specific tumor types that are driven by the different MYC… CONTINUE READING
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