The Expanding Role for ITAM-Based Signaling Pathways in Immune Cells

  title={The Expanding Role for ITAM-Based Signaling Pathways in Immune Cells},
  author={Clare L Abram and Clifford A. Lowell},
  journal={Science's STKE},
  pages={re2 - re2}
The immunoreceptor tyrosine-based activation motif (ITAM) is the primary signaling domain used by classical immunoreceptors, such as the antigen receptors on B and T lymphocytes and the Fc receptors (FcRs) on myeloid cells. The ITAM is contained in the intracellular region of subunits associated with these receptors, often in pairs, or is part of the cytoplasmic domain of the receptors themselves. Data from many investigators have demonstrated that ITAMs are both necessary and sufficient for… 

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Convergence of immunoreceptor and integrin signaling

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Data suggest that ligand binding to platelet alphaIIbbeta3 induces integrin cytoplasmic domain-dependent phosphorylation of FcgammaRIIa, which then enlists selected components of the immunoreceptor signaling cascade to transmit amplification signals into the cell.

The diverse functions of Src family kinases in macrophages.

  • C. AbramC. Lowell
  • Biology
    Frontiers in bioscience : a journal and virtual library
  • 2008
The cytoplasmic tyrosine kinase Src and its family members (SFKs) have been implicated in many intracellular signaling pathways in macrophages, but it has been difficult to implicate any given member of the family in any specific pathway.

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Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

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Evidence for the Requirement of ITAM Domains but Not SLP-76/Gads Interaction for Integrin Signaling in Hematopoietic Cells

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