The Expanding Role for ITAM-Based Signaling Pathways in Immune Cells

@article{Abram2007TheER,
  title={The Expanding Role for ITAM-Based Signaling Pathways in Immune Cells},
  author={C. Abram and C. Lowell},
  journal={Science's STKE},
  year={2007},
  volume={2007},
  pages={re2 - re2}
}
The immunoreceptor tyrosine-based activation motif (ITAM) is the primary signaling domain used by classical immunoreceptors, such as the antigen receptors on B and T lymphocytes and the Fc receptors (FcRs) on myeloid cells. The ITAM is contained in the intracellular region of subunits associated with these receptors, often in pairs, or is part of the cytoplasmic domain of the receptors themselves. Data from many investigators have demonstrated that ITAMs are both necessary and sufficient for… Expand
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