The Evolving Role of Taurolidine in Cancer Therapy

@article{Neary2009TheER,
  title={The Evolving Role of Taurolidine in Cancer Therapy},
  author={Peter M Neary and Patrick Hallihan and Jiang-huai Wang and Rolf Wilhelm Pfirrmann and David J. Bouchier-Hayes and H. Paul Redmond},
  journal={Annals of Surgical Oncology},
  year={2009},
  volume={17},
  pages={1135-1143}
}
Background and DesignTaurolidine consists of two taurinamide rings derived from the naturally occurring amino acid taurine. It has been utilized to prevent adhesions, as an antimicrobial, and as an anti-inflammatory agent. More recently, it has been found to exert antineoplastic activity. We reviewed the literature regarding taurolidine and its role in cancer treatment.Results and ConclusionTaurolidine induces cancer cell death through a variety of mechanisms. Even now, all the antineoplastic… 
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TLDR
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TLDR
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Taurine and inflammatory diseases
TLDR
This review summarizes the current knowledge concerning the role of taurine, TauCl and TauBr in the pathogenesis of inflammatory diseases initiated or propagated by MPO-derived oxidants.
Short-term treatment with taurolidine is associated with liver injury
TLDR
It is suggested that the taurolidine dose should be titrated in further investigations regarding liver injury and inflammation after short-term use in in vitro and in vivo models probably due to direct toxic effects on hepatocytes.
The antineoplastic antibiotic taurolidine promotes lung and liver metastasis in two syngeneic osteosarcoma mouse models and exhibits severe liver toxicity
TLDR
The findings of this study question the applicability of taurolidine for OS treatment and may suggest the need for caution regarding the widespread clinical use of t Taurolidine as an antineoplastic agent.
Taurolidine Sensitivity of Eryptosis, the Suicidal Erythrocyte Death
TLDR
Taurolidine triggers cell shrinkage and phospholipid scrambling of the erythrocyte cell membrane, an effect at least in part due to Ca2+ entry and paralleled by increase of ceramide abundance.
Taurine as Anticancer and Antiviral: Case Report and Prospective Update
TLDR
Taurine can be used to improve the existing therapeutic conditions by its utilization in clinical practice and beyond, according to this study.
Role of taurine, its haloamines and its lncRNA TUG1 in both inflammation and cancer progression. On the road to therapeutics? (Review)
TLDR
Basic knowledge about taurine and its TUG1 lncRNA is translated into potential therapeutic options directed against specific oncogenic signaling targets, thereby bridging the gap between bench and bedside.
Mechanism of taurine-induced apoptosis in human colon cancer cells.
TLDR
Demonstration of the molecular mechanism involved in the anti-tumor effect of Tau may be useful in the therapeutic target selection for p53-deficient colorectal cancer.
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In addition to its bactericidal and antilipopolysaccharide activity, taurolidine primes PMØs for enhanced antimicrobial activity and these effects appear mediated by the amino acid taurine.
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