The Evolving Role of Drug Metabolism in Drug Discovery and Development

@article{Yengi2006TheER,
  title={The Evolving Role of Drug Metabolism in Drug Discovery and Development},
  author={Lilian G. Yengi and Louis Leung and John Kao},
  journal={Pharmaceutical Research},
  year={2006},
  volume={24},
  pages={842-858}
}
Drug metabolism in pharmaceutical research has traditionally focused on the well-defined aspects of absorption, distribution, metabolism and excretion, commonly-referred to ADME properties of a compound, particularly in the areas of metabolite identification, identification of drug metabolizing enzymes (DMEs) and associated metabolic pathways, and reaction mechanisms. This traditional emphasis was in part due to the limited scope of understanding and the unavailability of in vitro and in vivo… CONTINUE READING
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