The Evolutionary Landscape of Alternative Splicing in Vertebrate Species

@article{BarbosaMorais2012TheEL,
  title={The Evolutionary Landscape of Alternative Splicing in Vertebrate Species},
  author={Nuno L. Barbosa-Morais and Manuel Irimia and Qun Pan and Hui Yuan Xiong and Serge Gueroussov and Leo J. Lee and Valentina Slobodeniuc and Claudia Kutter and Stephen Watt and Recep Çolak and TaeHyung Kim and Christine M. Misquitta-Ali and Michael D. Wilson and Philip M. Kim and Duncan T. Odom and Brendan J. Frey and Benjamin J. Blencowe},
  journal={Science},
  year={2012},
  volume={338},
  pages={1587 - 1593}
}
Whence Species Variation? Vertebrates have widely varying phenotypes that are at odds with their much more limited proteincoding genotypes and conserved messenger RNA expression patterns. Genes with multiple exons and introns can undergo alternative splicing, potentially resulting in multiple protein isoforms (see the Perspective by Papasaikas and Valcárcel). Barbosa-Morais et al. (p. 1587) and Merkin et al. (p. 1593) analyzed alternative splicing across the genomes of a variety of vertebrates… 

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Global regulatory features of alternative splicing across tissues and within the nervous system of C. elegans

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Mammalian splicing divergence is shaped by drift, buffering in trans, and a scaling law

It is demonstrated that non-adaptive mutations are often masked in tissues where accurate splicing likely is more important, and experimentally attribute such buffering effect to trans-regulatory splicing efficiency.

Evolution of splicing regulatory networks in Drosophila

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Does conservation account for splicing patterns?

A computational model that predicts absolute percent-spliced-in of cassette exons more accurately than previous models, despite not using any ‘hand-crafted’ biological features such as motif counts, suggests that one mechanism for the evolutionary transition from constitutive to alternative splicing is the emergence of cis-acting splicing inhibitors.

The evolution of alternative splicing in Drosophila

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