The Evolutionary History of Prosaposin: Two Successive Tandem-Duplication Events Gave Rise to the Four Saposin Domains in Vertebrates

@article{HazkaniCovo2002TheEH,
  title={The Evolutionary History of Prosaposin: Two Successive Tandem-Duplication Events Gave Rise to the Four Saposin Domains in Vertebrates},
  author={Einat Hazkani-Covo and Neta Altman and Mia Horowitz and Dan Graur},
  journal={Journal of Molecular Evolution},
  year={2002},
  volume={54},
  pages={30-34}
}
Abstract. Prosaposin is a multifunctional protein encoded by a single-copy gene. It contains four saposin domains (A, B, C, and D) occurring as tandem repeats connected by linker sequences. Because the saposin domains are similar to one another, it is deduced that they were created by sequential duplications of an ancestral domain. There are two types of evolutionary scenarios that may explain the creation of the four-domain gene: (1) two rounds of tandem internal gene duplication and (2) three… 
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Characterization of these four activator proteins, two of which were recently discovered, and their importance in human health and disease are reviewed, including their role in human lysosomal storage disorders.
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