The Evolutionarily Conserved CKAP2 Gene Is Located in Human Region 13q14.3 Often Rearranged in Various Tumors

Abstract

The human CKAP2 gene, which is involved in diffuse large B-cell lymphomas, was localized by screening the GeneBridge 4 somatic cell radiation hybrid panel by means of the polymerase chain reaction (PCR). The CKAP2 gene was mapped between the WI-15460 and WI-3673 markers at the boundary between regions 13q14.3 and 13q21.1, at the distance of 14.39 cR (with 4.8 cR per cM) from the WI-5867 framework marker (lod score > 2.26). The human CKAP2 gene displayed high homology to mouse and rat expressed orthologs. A CKAP2-like sequence was found in human chromosome 14 and assumed to be a pseudogene resulting from duplication and subsequent mutations of the CKAP2 gene on chromosome 13. A possible role of the CKAP2 gene in oncogenesis associated with deletions and rearrangements of region 13q14.3–21.1 is discussed.

DOI: 10.1023/A:1009087029511

Cite this paper

@article{Udina2004TheEC, title={The Evolutionarily Conserved CKAP2 Gene Is Located in Human Region 13q14.3 Often Rearranged in Various Tumors}, author={Irina G Udina and Ancha V. Baranova and A. A. Kompaniytsev and Galina Sulimova}, journal={Russian Journal of Genetics}, year={2004}, volume={37}, pages={105-107} }