The Evolution of the MAP Kinase Pathways: Coduplication of Interacting Proteins Leads to New Signaling Cascades

@article{Caffrey1999TheEO,
  title={The Evolution of the MAP Kinase Pathways: Coduplication of Interacting Proteins Leads to New Signaling Cascades},
  author={Daniel R. Caffrey and Luke A. J. O’Neill and Denis C. Shields},
  journal={Journal of Molecular Evolution},
  year={1999},
  volume={49},
  pages={567-582}
}
Abstract. The MAP-kinase pathways are intracellular signaling modules that are likely to exist in all eukaryotes. We provide an evolutionary model for these signaling pathways by focusing on the gene duplications that have occurred since the divergence of animals from yeast. Construction of evolutionary trees with confidence assessed by bootstrap clearly shows that the mammalian JNK and p38 pathways arose from an ancestral hyperosmolarity pathway after the split from yeast and before the split… Expand
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