The Evolution of the Differentiation-Specific Histone H1 Gene Basal Promoter

  title={The Evolution of the Differentiation-Specific Histone H1 Gene Basal Promoter},
  author={Marie Peretti and Saadi Khochbin},
  journal={Journal of Molecular Evolution},
The comparison of the rat H10 gene promoter sequence with that of known H10 genes showed a high evolutionary conservation of regulatory elements involved in the control of the basal transcription of the gene. This finding suggests that the regulation of H10 gene expression is also controlled by a very conserved mechanism within vertebrates. In order to confirm this hypothesis, we destroyed three major cis-acting elements in the H10 gene promoter by site-directed mutagenesis and showed that… CONTINUE READING


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