The Evolution of Mating Preferences and Major Histocompatibility Complex Genes

@article{Penn1999TheEO,
  title={The Evolution of Mating Preferences and Major Histocompatibility Complex Genes},
  author={Dustin J. Penn and Wayne K Potts},
  journal={The American Naturalist},
  year={1999},
  volume={153},
  pages={145 - 164}
}
  • D. Penn, W. Potts
  • Published 1 February 1999
  • Biology, Medicine
  • The American Naturalist
House mice prefer mates genetically dissimilar at the major histocompatibility complex (MHC). The highly polymorphic MHC genes control immunological self/nonself recognition; therefore, this mating preference may function to provide “good genes” for an individual's offspring. However, the evidence for MHC‐dependent mating preferences is controversial, and its function remains unclear. Here we provide a critical review of the studies on MHC‐dependent mating preferences in mice, sheep, and humans… Expand
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Major histocompatibility complex and mate choice in a monogamous rodent
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  • Biology
  • Behavioral Ecology and Sociobiology
  • 2005
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This is the first study investigating the role of the MHC in mate selection in an obligate monogamous rodent and finding that genetically similar instead of dissimilar mates seem to be the preferred choice. Expand
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References

SHOWING 1-10 OF 215 REFERENCES
The role of infectious disease, inbreeding and mating preferences in maintaining MHC genetic diversity: an experimental test.
TLDR
It is suggested that inbreeding avoidance may be the most important function of MHC-based mating preferences and therefore the fundamental selective force diversifying MHC genes in species with such mating patterns. Expand
Mating patterns in seminatural populations of mice influenced by MHC genotype
TLDR
Reproductive mechanisms, primarily mating preferences, result in 27% fewer MHC-homozygous offspring than expected from random mating, and mating preferences are strong enough to account for most of the MHC genetic diversity found in natural populations of Mus. Expand
No evidence for major histocompatibility complex–dependent mating patterns in a free–living ruminant population
  • S. Paterson, J. Pemberton
  • Biology, Medicine
  • Proceedings of the Royal Society of London. Series B: Biological Sciences
  • 1997
TLDR
It is concluded that MHC diversity in the St Kildan Soay sheep population is unlikely to be maintained by mating preferences and that, in contrast with evidence from experimental mice populations, MHC variation plays no role in the mating structure of this population. Expand
MHC–disassortative mating preferences reversed by cross–fostering
  • D. Penn, W. Potts
  • Biology, Medicine
  • Proceedings of the Royal Society of London. Series B: Biological Sciences
  • 1998
TLDR
It is shown that MHC–dependent familial imprinting potentially provides a more effective mechanism for avoiding kin matings and reducing inbreeding than self–inspection. Expand
Preweaning experience in the control of mating preferences by genes in the major histocompatibility complex of the mouse
TLDR
It is indicated that the same set of genes involved in regulation of immune function also determines, in part, mate choice and a male bias in favor of females whose MHC types differ from the male's parental MHC type could serve to promote heterozygosity at the MHC. Expand
Kin Recognition and the Major Histocompatibility Complex: An Integrative Review
TLDR
This review integrates recent advances in these fields around the central theme of kin recognition, showing how behavior, disease, and molecular genetics can be integrated in a context of evolution and natural selection. Expand
MHC-dependent mate preferences in humans
TLDR
The MHC influences both body odours and body odour preferences in humans, and that the women’s preferences depend on their hormonal status, which suggests that the MHC or linked genes influence human mate choice today. Expand
Genetic variability in the major histocompatibility complex: A review of non‐pathogen‐mediated selective mechanisms
TLDR
This review discusses the evidence for natural selection acting on MHC genes, in the form of homozygote deficiencies observed in human population isolates, and the two major candidates for mechanisms of non-pathogen-driven selection, maternal-fetal interactions and MHC-based mate choice. Expand
Non-random fertilization in mice correlates with the MHC and something else
TLDR
In an in vitro fertilization experiment with two inbred mouse strains congenic for their MHC, nonrandom MHC combinations in the blastocysts were found which may result from both possible choice mechanisms. Expand
The major histocompatibility complex and mating preferences of male mice
TLDR
It is found that oestrous females, tested either with male odours or tethered males, preferred males whose MHCtype was different from their own (Egid & Brown 1989), and time and ejaculation data are reported. Expand
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