The Evolution of Human Probiotics: Challenges and Prospects

  title={The Evolution of Human Probiotics: Challenges and Prospects},
  author={E. A. Trush and Elena A Poluektova and Allan G. Beniashvilli and O. S. Shifrin and Yu. M. Poluektov and Vladimir T. Ivashkin},
  journal={Probiotics and Antimicrobial Proteins},
In recent years, the intestinal microbiota has been found to greatly influence a number of biological processes important for human health and longevity. Microbial composition changes easily in response to external factors, such as an unbalanced diet, lack of physical activity, and smoking. Probiotics are a key factor in maintaining the optimal composition of the intestinal microbiota. However, a number of important questions related to probiotics, such as indication for prescription… 

Nanoencapsulation for Probiotic Delivery.

A brief overview of the current progress of different probiotic encapsulation methods is presented and the contemporary and emerging single-cell encapsulation strategies using nanocoatings for individual probiotic cells are highlighted.

Advancements in the Pharmaceutical Applications of Probiotics: Dosage Forms and Formulation Technology

An overview of the pharmaceutical applications of probiotics is provided and recent formulation approaches to optimize the delivery of probiotic with particular emphasis on various dosage forms and formulation technologies are covered.

The Use of Probiotics for Management and Improvement of Reproductive Eubiosis and Function

The present review summarizes the current knowledge on the biodiversity of the microbiota at the reproductive tract, possible changes in the case of dysbiosis, and their relationships with adequate reproductive health and functioning in both females and males and shows the findings of studies performed either on human or animal models.

Polymeric carriers for enhanced delivery of probiotics.

Metabolic profiles of Lactobacillus paraplantarum in biofilm and planktonic states and investigation of its intestinal modulation and immunoregulation in dogs.

Correlation analysis between L-ZS9-producing metabolites, dog intestinal microbiome diversity and dog blood immune indexes revealed the interaction between these three components, which might explain the mechanisms by which biofilm L- ZS9 regulated the intestinal microbiome and immunity activity of the host, through the production of various metabolites.

Applications of Probiotic-Based Multi-Components to Human, Animal and Ecosystem Health: Concepts, Methodologies, and Action Mechanisms

Two innovative profiling and monitoring methods, the thermophysical fingerprinting thermogravimetry–differential scanning calorimetry technique (TGA-DSC) of the whole multi-component powder preparations, and the Advanced Testing for Genetic Composition (ATGC) strain analysis up to the subspecies level, are presented, illustrated, and discussed in this review.

Evaluation of the Antioxidant Effects of Postbiotics and Paraprobiotics in Lactic Acid Bacteria Isolated from Traditional Fermented Sausages

According to the findings, antioxidant capacity of the postbiotics and paraprobiotics are strain-dependent and the post biotics have higher antioxidant activity than the paraprobiotic.

New Opportunities for Endometrial Health by Modifying Uterine Microbial Composition: Present or Future?

The microbes (mostly bacteria) identified in the endometrial microbiome studies are outlined, the current treatments offered for bacterial dysbiosis in the clinical setting, and the future possibilities such as pro- and prebiotics and microbial transplants for modifying uterine microbial composition are outlined.

Probiotics in hepatology: An update

Despite the progress in the study of probiotic drugs for the treatment of various liver diseases over the past decade, there are many unexplored and unclear questions surrounding this topic.

Potential Probiotic Bacillus subtilis Isolated from a Novel Niche Exhibits Broad Range Antibacterial Activity and Causes Virulence and Metabolic Dysregulation in Enterotoxic E. coli

It is shown that a recently isolated and potential novel strain of Bacillus subtilis from desert camel exhibits a strong antibacterial property and reveals potential mechanisms behind.



A consumer's guide for probiotics: 10 golden rules for a correct use.

Biofilm Forming Lactobacillus: New Challenges for the Development of Probiotics

This work aims to amalgamate information describing the biofilms of Lactobacillus strains which are used as probiotics, particularly L. rhamnosus, L. plantarum, L., reuteri, and L. fermentum to give origin to fourth generation probiotics.

Physiological protection of probiotic microcapsules by coatings

This review shows that coatings with the better performances in probiotics protection, against the harsh conditions of digestion, are chitosan, alginate, poly-L-lysine, and whey protein.

Do probiotic preparations for humans really have efficacy?

The scientific data published to date on the advantages of either mono- or multispecies probiotic products based on the outcome of the most significant clinical trials are reported.

Probiotics: determinants of survival and growth in the gut.

Beneficial effects may accrue from exogenously administered probiotics, often administered with prebiotics, or by endogenous bifidobacteria and lactobacilli, whose metabolic activity and growth may also be enhanced by the administration of prebiotic substances.

Probiotics and Prebiotics.

  • M. Floch
  • Medicine
    Gastroenterology & hepatology
  • 2014
Prebiotics are non-digestible carbohydrates which act by promoting the growth and/or activity of probiotic bacteria in the gut, and Synbiotics contain prebiotics and probiotics in the same preparation.

The Effects of Probiotics and Symbiotics on Risk Factors for Hepatic Encephalopathy: A Systematic Review

Although further research is warranted, probiotics and symbiotics should be considered as an alternative therapy for the treatment and management of HE given the results reported in this systematic review.

Encapsulation of beneficial probiotic bacteria in extracellular matrix from biofilm-forming Bacillus subtilis

A novel cultivation system that enables co-culturing of Bacillus subtilis along with probiotic lactic acid bacteria (LAB) by increasing production of the extracellular matrix by B. subtil is developed and the results of this study will provide a novel technique of using a natural system for preservation and delivery of probiotics to humans.

Health benefits of probiotics: are mixtures more effective than single strains?

Based on a limited number of studies, multi-strain probiotics appear to show greater efficacy than single strains, including strains that are components of the mixtures themselves, but whether this is due to synergistic interactions between strains or a consequence of the higher probiotic dose used in some studies is at present unclear.